May 10th, 2022 Webinar Speakers

Our next webinar will take place via the internet on Tuesday May 10th at 7 PM EDT/12 AM BST. Sign up on our mailing list to receive the Zoom link!

We hope to see/hear from you all at one of our sessions or as one of the next speakers. If you are an early career scientist and would like to present your research, don't hesitate to submit an abstract today! For now, please learn more about our current speakers and their research below. We also thank the generous support from Cell Reports Physical Science, Merck, Janssen, and the Royal Society of Chemistry.

Our featured speakers this week are Hannah Slocumb (Graduate Student, UC Irvine, USA), and Matthew Evans (Graduate Student, Victoria University of Wellington, New Zealand). The guest moderator is Dr Rebecca Ruck from Merck.


HANNAH SLOCUMB (on Twitter @HannahSlocumb5)

Biography: I am a third year chemistry PhD candidate in the Vy Dong group at University of California, Irvine, and I received my B.Sc. from Harvey Mudd College. In the Dong group I have worked on the asymmetric hydroamination of dienes using pyrazoles through chiral Pd-catalysis. A wide range of allylic pyrazoles can be synthesized, and the proposed mechanism features a unique ligand-ligand hydrogen transfer. In my free time I enjoy hanging out with my dog Frankie.

Title of Talk: "Enantioselective Addition of Pyrazoles to Dienes"

Abstract: Pyrazoles represent a vital motif found in pharmacologically active molecules. We report the first enantioselective addition of pyrazoles to 1,3-dienes. Secondary and tertiary allylic pyrazoles can be generated with excellent regioselectivity. Mechanistic studies support a pathway distinct from previous hydroaminations: a Pd(0)-catalyzed ligand-to-ligand hydrogen transfer (LLHT). This hydroamination tolerates a range of functional groups and advances the field of diene hydrofunctionalization.

MATTHEW EVANS (on Twitter @EvansInorganic)

Biography: Matthew began his research in main-group chemistry under the tutelage of Prof. Robin Fulton at Victoria University of Wellington, with a focus on the reduction of unsaturated molecules by N-heterocyclic germanimines. Matthew continued his research in main-group chemistry for his PhD under the supervision of Prof. Martyn Coles and Dr. Mathew Anker. Since starting his PhD, Matthew has investigated the synthesis and reactivity of low-valent aluminyl anions for the activation of small molecule substrates. Matthew is particularly interested in the conversion of greenhouse gases into value-added products by main-group reagents.

Title of Talk: "Diversifying the Structure of Group 1 Aluminyls"

Abstract: Aluminium is an earth-abundant metal that can be utilised in the +1 oxidation (low-valent) state to affect the functionalisation of challenging small molecule substrates. While the neutral aluminium(I) systems have had some success in this area, the group 1 aluminyls have been shown to act as potent reducing agents capable of reducing greenhouse gases, such as CO2 and N2O. The group 1 aluminyls contain a low valent aluminium(I) centre that is supported by a dianionic ligand charge-balanced by a group 1 metal cation. The cation plays a vital role in the reactivity of these complexes and dictates the structure of the aluminyl in both the solid- and solution-state. Until recently, all of the reported aluminyl systems were exclusive to potassium. This talk details the synthesis of the first complete series of group 1 aluminyls, isolated as contacted dimeric pairs (CDPs), and their conversion into the corresponding monomeric ion-pairs (MIPs) and separated ion-pairs (SIPs) using appropriate chelating ligands.

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